Tag: Prostate cancer

Higher BMI in Youth Impacts Future Cancer Risks
Health

Higher BMI in Youth Impacts Future Cancer Risks

High BMI at the time of conscription was linked to an increased risk of 17 malignancies, including lung, head and neck, brain, thyroid, esophageal, stomach, pancreatic, liver, colon, rectal, kidney, and bladder cancer, as well as malignant melanoma, leukemia, myeloma, and lymphoma (both Hodgkin's and non-Hodgkin's). For several cancer types, the risk was already enhanced with a BMI of 20-22.4, which is within the normal weight range (18.5-24.9). Cancers of the head and neck, esophagus, stomach, pancreas, liver, and kidney were among them, as were malignant melanoma and non-Hodgkin's lymphoma. "This suggests that the current definition of normal weight may be applicable primarily for older adults, while an optimal weight as a young adult is likely to ...
Genetic Chronicles Marks USC’s Quests for Prostate Cancer Insights
Health

Genetic Chronicles Marks USC’s Quests for Prostate Cancer Insights

With these findings, the researchers improved a system they developed for measuring genetic risk so that it was more effective in predicting who would or wouldn't develop prostate cancer — even distinguishing between the likelihood of aggressive and less serious cases among men of African descent. The finding that higher risk scores based on the 451 variants correlated with more-aggressive disease in men of African ancestry is a meaningful step toward improving early detection and making better-informed decisions about screening. Advertisement The study builds on 2021 research documented in the same journal that found 269 genetic variants correlating with prostate cancer risk, based on a sample of nearly 235,000 men. USC'...
Diabetes Drug Metformin Shows Promise Against Prostate Cancer
Health

Diabetes Drug Metformin Shows Promise Against Prostate Cancer

"Where we see metformin having the biggest impact is in patients who've just been diagnosed with prostate cancer," says Alex Papachristodoulou, Ph.D., associate research scientist, who conducted the research in the lab of Cory Abate-Shen, Ph.D., chair of the Department of Molecular Pharmacology & Therapeutics. Most patients with new diagnoses of prostate cancer have low-grade tumors that are not treated and are instead monitored by active surveillance. But some of these tumors will become more aggressive and potentially life-threatening. Advertisement "Metformin could be given to patients under surveillance with high-risk tumors when there's still time to prevent progression to advanced disease," A...