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Kashmir doctors discover PAX2 gene variant linked to rare kidney-eye disorder

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Kashmir doctors discover PAX2 gene variant linked to rare kidney-eye disorder

The landmark study, published in ‘Kidney International’—the official journal of the International Society of Nephrology—identified a previously unknown mutation in the PAX2 gene, broadening scientific understanding of PAX2-related disorders and adding a new genetic variant to global medical literature.

The research was carried out by Dr. Jawad Iqbal Rather, Assistant Professor in the Department of General Medicine, and Dr. Rayees Ahmad Sofi, Associate Professor and In-charge Head of the Department of Ophthalmology at GMC Anantnag. The paper, titled “Iris Coloboma in PAX2-Related Disorder,” was published on July 27, 2026, in one of the world’s highest-ranked nephrology journals, which has an Impact Factor of 21.8 and a CiteScore of 23.1.

The study documents the case of a 22-year-old man who presented with chronic kidney disease and gout. During a comprehensive ophthalmic evaluation, doctors also identified bilateral cataracts and iris coloboma—a rare congenital defect in which a portion of the iris, the coloured part of the eye, fails to develop completely before birth.

To determine the underlying cause of the unusual combination of symptoms, the patient underwent whole-exome sequencing, an advanced genetic test that examines thousands of genes simultaneously. The findings were subsequently validated using Sanger sequencing, regarded as the gold standard for confirming genetic mutations.

The analysis revealed a previously unreported heterozygous missense mutation in the PAX2 gene, designated as c.87C>G (p.Asn29Lys).

According to the researchers, multiple computational prediction models classified the variant as damaging, while it met the American College of Medical Genetics and Genomics (ACMG) criteria for being “likely pathogenic,” indicating that it is likely responsible for causing the disease.

The researchers noted that the genetic variant has not previously been documented in the international ClinVar database, making it an entirely novel discovery.

They said the combination of chronic kidney disease, gout, bilateral cataracts, iris coloboma and molecular confirmation of a previously unknown PAX2 mutation distinguishes the case from all previously reported cases worldwide.

The findings, they said, expand the known clinical spectrum of PAX2-related disorders and underscore the importance of considering genetic testing in patients who present with kidney disease alongside unexplained eye abnormalities.

The authors observed that an early genetic diagnosis can facilitate timely treatment, enable appropriate family counselling and improve long-term clinical monitoring of affected individuals.

Doctors said the discovery demonstrates the value of multidisciplinary collaboration in diagnosing rare disorders and highlights the growing research capabilities of institutions in Jammu and Kashmir.

“This discovery not only expands the global understanding of PAX2-related disorders but also reinforces the importance of detailed ophthalmic evaluation and advanced genetic testing in patients with unexplained kidney disease. Early diagnosis can make a significant difference in patient management, family screening and long-term follow-up. We are proud that this work from GMC Anantnag has contributed new knowledge to international medical literature,” they said.

Greater Kashmir

Sericulture Deptt sends farmers to Karnataka for exposure to modern silk farming techniques

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Sericulture Deptt sends farmers to Karnataka for exposure to modern silk farming techniques

The Sericulture Development Department, Jammu and Kashmir, on Monday flagged off a group of progressive silkworm rearers for a 10-day exposure visit to Karnataka under the Holistic Agriculture Development Programme (HADP) 2026-27.

The exposure visit was flagged off by Director Sericulture J&K, Ajaz Ahmad Bhat, as part of the department’s efforts to strengthen the sericulture sector and equip farmers with modern technologies and scientific practices.

Organised in collaboration with the Central Silk Board (CSB), Ministry of Textiles, Government of India, the programme aims to expose participating farmers to advanced sericulture techniques and successful production models adopted in Karnataka.

The tour, which will continue until August 12, includes visits to leading sericulture institutions and commercial establishments in Bengaluru, Ramanagara, Sidlaghatta and Mysuru. During the visit, the farmers will gain first-hand experience of modern silk farming practices through visits to cocoon auction markets, private silk reeling units, Automatic Reeling Machine (ARM) facilities, research and training institutes. They will also interact with scientists, technical experts and progressive entrepreneurs associated with the silk industry.

The programme is designed to familiarise participants with scientific methods of mulberry cultivation, silkworm rearing, seed production, cocoon marketing, disease management, silk reeling and value addition. The department expects the exposure to help farmers adopt commercially viable practices that improve cocoon quality, productivity and incomes in Jammu and Kashmir.

Speaking on the occasion, Director Sericulture Ajaz Ahmad Bhat said exposure visits play a crucial role in bridging the gap between traditional farming methods and modern technologies.

He urged the participants to make the most of the opportunity by closely observing best practices followed in Karnataka and sharing the knowledge gained with other silkworm rearers after their return.

Bhat reiterated the department’s commitment to strengthening the sericulture sector through capacity building, technology transfer and continuous extension support to farmers.

The participating farmers thanked the Sericulture Development Department and the Jammu and Kashmir Government for providing them with the opportunity. They expressed confidence that the practical exposure would help improve their farming practices and encourage wider adoption of scientific sericulture techniques across the Union Territory.

The department said it remains committed to promoting scientific sericulture and transforming Jammu and Kashmir into a leading producer of high-quality bivoltine silk through sustained technological interventions, skill development and farmer-centric initiatives.

Greater Kashmir

Kashmir United FC clinch 4–2 victory over Sports Council Football Academy

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Kashmir United FC clinch 4–2 victory over Sports Council Football Academy

Kashmir United FC produced a commanding second-half display to defeat Sports Council Football Academy (SCFA) 4–2 in an exciting Srinagar Premier League 2026 encounter played at TRC Synthetic Turf, Srinagar.

The tournament is being organised under the District Football Association (DFA) Srinagar.

The match, as per a DFA statement, began at a high tempo, with both sides showing attacking intent from the opening whistle. Sports Council Football Academy started brightly and looked dangerous in the final third, but Kashmir United FC responded with composed football and clinical finishing. The first half ended with Kashmir United holding a 2–1 advantage, setting the stage for an entertaining second period.

Greater Kashmir

Anjuman-e-Sharie Shian commences Arbaeen-e-Hussaini (AS) mourning processions

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Anjuman-e-Sharie Shian commences Arbaeen-e-Hussaini (AS) mourning processions

The Jammu & Kashmir Anjuman-e-Sharie Shian has commenced its annual Arbaeen-e-Hussaini (AS) commemorations and mourning processions across various parts of the Kashmir Valley to mark the 40th day of the martyrdom of Imam Hussain (AS).

As part of these observances, a grand religious gathering was held at Labertal, Budgam, where a Majlis-e-Aza was followed by a large mourning procession led by the President of the organization, Hujjat-ul-Islam wal-Muslimeen Aga Syed Hassan Mosavi Al-Safavi.

Tens of thousands of mourners participated in the procession with profound devotion, reverence, and solemnity, said a press release.

Prior to the procession, prayers were offered in congregation at the Imam Bara Labertal under the leadership of Hujjat-ul-Islam wal-Muslimeen Aga Syed Hassan Mosavi Al-Safavi. 

Following the prayers, participants paid heartfelt tribute to the martyrs of Karbala (AS) and renewed their pledge to uphold the timeless ideals and mission of Imam Hussain (AS).

Addressing the Majlis-e-Aza, Hujjat-ul-Islam Aga Syed Mujtaba Abbas Mosavi Al-Safavi stated that the monumental gathering of Arbaeen is not merely a historical commemoration but a divinely ordained religious symbol rooted in the Holy Qur’an, the Sunnah of the Holy Prophet Muhammad (PBUH), and the teachings of the Ahlul Bayt (AS). He said that expressing grief for the friends of Allah and commemorating the unparalleled sacrifice of Imam Hussain (AS) constitute an integral part of Islamic teachings. 

Referring to Prophet Ya’qub’s (AS) profound grief over the separation from Prophet Yusuf (AS) and the Holy Prophet’s (PBUH) tradition of offering condolences, he asserted that mourning and the expression of sorrow are firmly established by the Qur’an and the Prophetic tradition.

Aga Syed Mujtaba Abbas Mosavi Al-Safavi further said that Imam Hussain (AS), through the supreme sacrifice of himself, his family, and his loyal companions in Karbala, sought to liberate humanity from ignorance, oppression, and misguidance while safeguarding the true spirit and values of Islam. He observed that the presence of millions of devotees of the Ahlul Bayt (AS) from across the world in Karbala on the occasion of Arbaeen stands as a living testimony that the message of Imam Hussain (AS) remains vibrant and continues to serve as a universal beacon of justice, truth, freedom, steadfastness, and moral guidance. Citing traditions of the Ahlul Bayt (AS), he highlighted the immense spiritual significance and divine rewards associated with the visitation of Imam Hussain (AS), particularly the pilgrimage of Arbaeen.

Paying glowing tribute to Hazrat Zainab al-Kubra (SA) and Imam Zain-ul-Abideen (AS), he said that it was their unparalleled patience, resilience, courage, and unwavering commitment that preserved the true message of Karbala for all generations and transformed the triumph of truth over tyranny into an eternal chapter of human history. He urged the faithful to embody the spirit of Arbaeen in their daily lives by upholding justice, piety, sincerity, patience, service to humanity, and steadfast resistance against oppression.

Concluding his address, Aga Syed Mujtaba Abbas Mosavi Al-Safavi prayed for the unity of the Muslim Ummah, lasting peace and stability, and the early reappearance of Imam al-Mahdi (ATFS).The commemorative gathering concluded with special prayers for peace and stability in Jammu & Kashmir and the wider Muslim world, unity among Muslims, and the dignity, justice, and well-being of oppressed people across the globe.

Greater Kashmir

Prashant Kishor wins Bankipur, Bihar bypoll, setback for BJP

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Prashant Kishor wins Bankipur, Bihar bypoll, setback for BJP

Jan Suraaj Party chief Prashant Kishor won the Bankipur Assembly bypoll on Monday, defeating the BJP candidate and ending the party’s decades-long hold over the prestigious constituency, The Times of India (TOI) reported.

According to the Election Commission figures after 29 rounds of counting, Kishor secured 61,075 votes, leading BJP candidate Neeraj Kumar, who polled 42,111 votes, by 18,964 votes. RJD candidate Rekha Kumari finished third with 13,625 votes.

Speaking after his victory, Prashant Kishor said the result was more than the election of an MLA and described it as a message to the BJP leadership, TOI reported.

Referring to the BJP’s long dominance in the constituency, he said, “The 30-year stronghold fell in 30 days,” and stressed that Bihar needs leadership focused on education, employment and stopping migration from the state. Kishor thanked the voters for their support and said he would also work to win the confidence of those who did not vote for him.

Greater Kashmir

Sharif’s PML-N set to form government in PoK; sweeps second phase polls amid violence, rigging allegations

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Sharif’s PML-N set to form government in PoK; sweeps second phase polls amid violence, rigging allegations

The Pakistan Muslim League (Nawaz) swept the second phase of elections in Pakistan-occupied Kashmir (PoK), winning 14 out of 18 contested seats, which will enable it to form a government in the region.

The Pakistan People’s Party won the remaining four seats, PoK’s Election Commissioner Ghulam Mustafa Mughal said on Monday.

The second phase of the ongoing PoK polls was held on Sunday, amid violence and rigging allegations. One person was killed, and several were injured in the violence.

Greater Kashmir

DIG JSK initiates Virtual appearance for grievance redressal for Police personnel

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DIG JSK initiates Virtual appearance for grievance redressal for Police personnel

Deputy Inspector General of Police (DIG-P), Jammu-Samba-Kathua (JSK) range Shridhar Patil on Monday announced to initiate a “Virtual appearance for grievance redressal” mechanism for the Police personnel.

“The DIG-P, JSK range has commenced the practice of holding an Orderly Room every Monday and Thursday at RPHQ Jammu for the redressal of genuine service-related grievances,” read the post on his official social media handles.

The initiative is aimed at facilitating aggrieved Police personnel confronting any legitimate service-related grievance as they will not be required to visit Police Headquarter to seek redress and will be able to get it resolved through virtual hearing. 

Greater Kashmir

NC to continue Statehood campaign until Centre fulfils promise: Nasir Aslam Wani

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NC to continue Statehood campaign until Centre fulfils promise: Nasir Aslam Wani

Addressing reporters in Baramulla, Wani said the National Conference’s recent protest at JantarMantar in New Delhi marked the beginning of a sustained democratic campaign to press the Union Government for the restoration of statehood.

“Our Jantar Mantar protest was meant to remind the Centre that the promise made to the people of Jammu and Kashmir has still not been fulfilled,” Wani said.

He recalled that following the abrogation of Article 370 in August 2019, the Centre had outlined a roadmap comprising the delimitation of Assembly constituencies, conduct of Assembly elections and restoration of Jammu and Kashmir’s statehood.

“Two of those commitments—delimitation and Assembly elections—have been completed. The only remaining promise is the restoration of statehood, and that should now be honoured,” he said.

Describing the issue as one of democratic rights and public aspirations, Wani said the National Conference would continue to pursue the demand through peaceful and democratic means until statehood is restored.

“This is not a one-day exercise. Our efforts will continue until Jammu and Kashmir regains its statehood,” he asserted.

Wani said the protest in the national capital witnessed the participation of the party’s entire leadership, including National Conference president Dr Farooq Abdullah, legislators and other senior functionaries, reflecting the party’s collective commitment to the issue.

He said the party leadership would soon deliberate on the next phase of the campaign and decide its future course of action to keep the demand for statehood alive.

The National Conference had staged a demonstration in New Delhi on the opening day of Parliament’s Monsoon Session, demanding the immediate restoration of Jammu and Kashmir’s statehood.

Led by Dr Farooq Abdullah, party leaders and workers assembled outside the Jammu and Kashmir House carrying placards with slogans such as “Apna Wada Pura Karo”, “Restore Rights and Dignity of People of J&K” and “Restore Full Statehood”, urging the Centre to implement its stated commitment.

Greater Kashmir

Expanding cloud mass may cause cloudbursts in Jammu

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Expanding cloud mass may cause cloudbursts in Jammu

As per weatherman, weather activity on a similar pattern will continue till August 7-8.

“Light rainfall was experienced at many stations of Jammu region on August 3. Different parts of the region will witness light to moderate rains during the next two days as well, commencing during the intervening night of August 3 and 4. However, higher reaches in Chenab valley and Udhampur, Reasi may witness high intensity rainfall triggering cloudbursts and flash floods. After Wednesday, August 6, the intensity will reduce,” stated Dr Mahender Singh, Chief Scientist and In-charge Agrometeorology, SKUAST-Jammu.

As per earlier forecast, moderate to heavy showers lashed several parts of the region on Monday (August 3, 2026) as well. Particularly Rajouri witnessed an intense spell of heavy showers leading to flood alerts in several parts of the district. Parts of Jammu and Udhampur too witnessed brief spells of intense rainfall.

“In terms of intensity, 15 to 20 mm of rainfall was recorded in different parts of Jammu region while Rajouri registered 20 to 25 mm of rainfall,” Singh shared.

Earlier the met department forecast had mentioned the rapid cloud mass expansion over Jammu region on August 3 and 4. Even during the next two days, although prolonged rainfall is not expected, there remains a very high risk of flash floods due to intense localised downpours and isolated cloudburst events too cannot be ruled out, with the possibility of landslides and shooting stones in vulnerable hilly areas.

Weather advisories, issued by the divisional, district authorities and Police, cautioning people in vulnerable stretches to stay alert continue to be in place.

The heavy to normal rainfall in the month of July has already ended the deficit spell in Jammu division with many of its districts recording surplus precipitation.

As per the Met department prediction, in the next three to four days, the maximum temperature in Jammu will swing between 33 to 35 degrees Celsius, followed by hot and humid weather conditions.

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Water levels surge in Kangan areas

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Water levels surge in Kangan areas

Meanwhile, a landslide hit Srinagar-Leh National Highway near Sarbal area of Sonamarg on Monday afternoon which blocked the road and resulted in the disruption of traffic.

However, the Border Roads Organisation (BRO), Traffic Police, and other agencies pressed machinery into action and the restoration work was carried to ensure the traffic is restored.

Meanwhile, a residential house suffered extensive structural damage in the Ganderbal district after sudden high-velocity winds swept through parts of the area, blowing off its entire rooftop.

According to locals, the incident occurred in Bakura area of Ganderbal district during a spell of erratic weather accompanied by strong wind gusts.

The intense pressure ripped the tin roof completely off the concrete base, throwing debris on the road.

Family members inside the house at the time of the incident managed to evacuate to safety.

No casualties or injuries were reported, though household belongings and property in the upper floor sustained significant damage.

Shortly after the incident, local residents gathered at the site to assist the affected family in clearing the debris.

An electric pole was also damaged in the incident.

Authorities have urged residents to exercise caution as unpredictable weather conditions and high winds continue across vulnerable pockets of the region.

Greater Kashmir

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